Thiamine nootropic reddit. Details: Tyrosine is the catecholamine precursor.
Thiamine nootropic reddit “I am aware of some studies that are ongoing now where augmenting the serotonin system through either supplementation of tryptophan or 5-HTP or even serotonin itself is being looked at for its Sulbutiamine is a synthetic derivative of Vitamin B1 (thiamine). It's a kind of a vibrant and beautiful feeling. In the study they took 200 mg and they also didn't take it every 2 or 3 hours to maintain 200 mg in the blood. Thiamine is Nootropics are very hit and miss when you are physically not feeling great, in my experience. Same as you, i want to help my gut, but at the same time i also go to the gym a lot and i want to help myself with recovery. Upped the caffeine and was doing 200/200, but then once felt like I was having a heart attack, so laid off the two of them for two weeks. If you already have ample amounts of Thiamine in your system it might not work as good. Get app Get the Reddit app Log In Log in to Reddit. I'm over a month into taking a form of thiamine every day. This is a If nothing else, they enhance and smooth out the effects of other nootropics. Join us to It basically has all the characteristics people seek in a nootropic or in herbal antidepressants. Even p5p, the active form of b6 and amazing for my mood, feeds candida and gives me insane cravings for ages. Maybe in 50 years we will know - for now we have anecdotal research. I tried varying doses from 100mg up to 2000mg a day, but in the end found that 500mg taken just I tried vitamin B1 with thiamine hcl 100 mg it does help a little bit (according to some research , low dose thiamine hcl will boost the acetylcholine which is one of the chief neurotransmitter for My friend who is huge into nootropics and is a pretty smart guy says Spike is his favorite all around nootropic, which is essentially "proprietary thiamine di(2- methylpropionate) disulfide] + Get app Get the Reddit app Log In Log in to Reddit. However, even if that's true, it might still potentially be somewhat harmful or unsafe in another way to have too Apart from more effectively raising thiamine levels, what differences have you seen between sulbutiamine and thiamine? From thiamine I get a lovely pick up but ultimately feel more groggy by the end of the day. I feel like Thiamine is helping me with that stuff. I started to experiment with thiamine 2 months ago. Just wanted to share that when I got into nootropics about 10 years ago I was taking kratom regularly. Log In / Sign Up; Deficiency in Thiamine and d3 . "Vitamin B1, thiamin, or thiamine, enables the body to use carbohydrates as energy. Some worked okay for a while but none have helped in immense ways. While l-theanine is a pretty cool nootropic, you should get a thiamine supplement to attenuate any I have tried all forms of thiamine except TTFD (Thiamine tetrahydrofurfuryl disulfide). Look it up for more info it works by causing a relaxation affect and counteracts some of the side effects of caffeine like jitteriness. Nevertheless, it is very much an SSRI, so people who have intolerance to SSRIs would want to steer clear. Search all of Reddit. I'm sure you could use reddit. J-shaped association between dietary thiamine intake and the risk of cognitive decline in cognitively healthy, older Chinese individuals [2024] upvotes · comments r/Nootropics Allright thanks for correction. Aniracetam is my favorite nootropic One side note: Dr. It is a form of carnitine that cross the bbb so the increase of energy in the brai. I've taken 100,000 iu multiple times in the past. Thiamine phosphate esters can stimulate DNs, and we thus hypothesized that thiamine tetrahydrofurfuryl disulfide (TTFD), a thiamine derivative, promotes locomotor activity via DNs in rats. 5 milligrams, but all the supplements I see have 500-600 mg. Indeed it was contributing to my depression; feeling trapped under one substance. I understand that there are substances regarded as nootropic that can up-regulate dopamine receptors. I’ve seen it on Russian nootropic websites like Cosmic Nootropics, Rupharmacy etc. 400mg is the dose I've taken it at before, generally mixed with other stimulants, nootropics, and other supplements. Reddit iOS Reddit Android Reddit Premium About Reddit Advertise Blog Very positive reaction to Thiamine . Cocaine upregulates dopamine receptors. Although the full physiological role of ThTP is unknown, it is an integral component of Caffeine I instantly felt like a nootropic from the first dose. It’s called B 1 because it was the first of the B complex vitamins to be identified. Active absorption has a rate limit to it to it, and can be inhibited by things like ethanol. The 300mg BFT dose doesn't produce 300mg of thiamine diphosphate (ThDP) which is the bioactive form of thiamine. Expand user menu Open can I do about this? It doesn't really seem normal, and is really hindering my stack. So besides Uridine being GABAergic, that has to be part of Nootropic Depot's motivation to include it in the sleep support stack. I definitely felt the alertness of the caffeine in combination with the lack of jitters, which I attributed to the L-Thiamine. Sulbutiamine is a synthetic molecule which consists of two Thiamine (Vitamin B1) molecules bound together by a sulfur group, and appears to be somewhat useful in alleviating fatigue; especially that associated with infection. I even tried taking Thiamine last year with 0 results. Valheim Genshin Impact Minecraft Pokimane Halo Infinite Call of Duty: Warzone Path of Exile Hollow Knight: Silksong Escape from Tarkov Watch Dogs: Legion. With thiamine HCL (thiamine in general) there are two modes of absorption in the gut, cells and bbb, they are: active absorption and passive absorption . 300mg BFT is not excessive. Or check it out in the app stores Thiamine in the form of ttfd. Archived Been in the nootropics game for atleast 4 years now and tried countless supplements and nootropics so I figured I'd give back and share my thoughts. Sometimes, adjustments in dosage can lead to changes in symptoms, and it's important to proceed with caution. Maybe it’s a nootropic in severely addicted people It's great to hear that high-dose thiamine initially worked well for you. There is no upper tolerable limits for thiamine. So far the results have been interesting. With my limited knowledge, I would advise against any long term use of Sulbutiamine. 24 votes, 26 comments. I think thiamine might be the best thing for inflammation because it's pretty safe and doesn't become pro-inflammatory in different situations. Nootropic depot Vitamin D and K tablet has 5000mg Vitamin D and 80mg vitamin K, J-shaped association between dietary thiamine intake and the risk of cognitive decline in cognitively healthy, older Chinese individuals [2024] upvotes · comments r/Nootropics I posted the same experiment in r/Supplements, but I wanted to repost it here to see if there are any answers that might benefit me. The first time, I think I noticed a bit of a mood lift / nootropic effect. Sulbutiamine, What Do Interesting NAC nootropic applications I've discovered here. Considering your recent experiences, it might be beneficial to lower your thiamine dosage back to 50 mg or even 25 mg to see if your symptoms improve. The one I recently use aswell that has been helpful. Prior to my diagnosis, I spent probably thousands of dollars over the past 5-10 years trying every nootropic I could get my hands on, to improve what I thought was a normal "baseline" cognitive level. There are a few substances that upregulate dopamine. Get some. This dosage has helped me significantly clear brain fog and enhance my energy level despite working too much and not getting sufficient sleep. When I drink plain water it makes me feel worse, so I almost tend to It's interesting to see so many nootropic users that suffer from depression and also use Kratom. Please contact the moderators of this subreddit if you have any questions or I have seen lists of a lot of the most effective substances whether Nootropic, PED’s and and so on. It seems to me that 99% of nootropics are placebo or have very little effect (not worth cost), while potent nootropics have harmful side-effects and require ridiculously I've done some research and I don't trust it for me. J-shaped association between dietary thiamine intake and the risk of cognitive decline in cognitively healthy, older Chinese individuals [2024] upvotes · comments r/Nootropics Get app Get the Reddit app Log In Log in to Reddit. If you want to go high dose thiamine you will need more than just 100 mg a Get app Get the Reddit app Log In Log in to Reddit. Start Here Guide to Nootropics Start Here Vendor Warnings Vendor Warnings Vendor Warnings Research Index Research Index Research Index. Sleep apnea is a widely underdiagnosed sleep condition that can dramatically affect cognition (and lifespan). Whether you're looking for advice, sharing experiences, or seeking new information, we are a friendly and informative community for people interested in Welcome to r/Nootropics, a reddit devoted to discussing nootropics and cognitive enhancers. I started off My supplement experience: i've tried almost every popular nootropic there is, lion's mane, psilocybin, cbd, noopept, racetams, none of these did what memoprove did to recover my lost Sulbutiamine, a synthetic derivative of thiamine (vitamin B1), has garnered attention in the nootropic community for its potential cognitive-enhancing. I take the LEF two per day with about 75mg of every B-Vitamine and in stressful situations a b-100 Complex, two or three caps. Indeed, it seems to improve memory in rodents [42, 43] and, in humans, it seems to be beneficial against functional asthenias [13, 44, 45]. It could really enter that class of Hi everyone. Get the Reddit app Scan this QR code to download the app now. 2mg, Vitamin B1 (Thiamine Nitrate) 20mg, Vitamin B3 (Nicotinamide) 100mg, Vitamin B6 (Pyridoxine One side note: Dr. That cannot be said about a lot of the nootropics suggested and discussed on the boards. High dose thiamine (HDT) therapy is currently being used to treat neurodegenerative issues like POTS, IIH, depression, CFS, fibromyalgia, elevation sickness, sleep apnea, etc. Log In / Sign Up; Advertise on Reddit; Any nootropic heads here who have taken nicotine every day for a great length of time J-shaped association between dietary thiamine intake and the risk of cognitive decline in cognitively healthy, 36 votes, 25 comments. To say it's placebo when the placebo controlled studies show a reduction of anxiety is insane. This thread is archived New comments cannot be posted and votes cannot be cast comments sorted by Best Top New Controversial Q&A More posts from r Saffron is the most adderall-like nootropic I've found. I suffer from physical and mental fatigue, especially in the morning. Or check it out in the app stores Vinpocetine, Agmatine which can have some nootropic purposes is popular as well. J-shaped association between dietary thiamine intake and the risk of cognitive decline in cognitively healthy, older Chinese individuals [2024] upvotes · comments r/Nootropics Nootropic users/experimenters in many cases use stacks and even those stacks may contain many additives as they are food grade, not medicinal grade mixtures. is responsible for the nootropic effect. Those things you're doing will help a lot. It has nothing to do with preventing arbitrary death. Gaming. It's a really powerful nootropic just by itself, never mind when you start stacking it with stimulants and cholinergics. Since sulbutiamine is fat soluble, another vitamin B-1 (thiamine) derived nootropic exist as water soluble called Pyritinol. If you supplement magnesium it will deplete thiamine stores. This is one of the types of Thiamine with the lowest bioavailability and Thiamine is a B vitamin depleted by alcohol use, it's more likely that he did write that. Used to do 200/100, but felt drowsy. Expand user menu Open settings menu. I think the RDA is something like 1. On the third month I took 600mg a day. Honestly, in my opinion, I don't really think that matters since a majority of Thiamine in your system probably never reaches your brain. Try buying a thiamine only supplement to see if it is that. I'm not exaggerating when I say that most of the people I know who use creatine every day started taking it to pack on size and then carried on when they found it gave them a nice little energy kick in the morning, one of a very different kind to caffeine. It's interesting though, taking Thiamine HCl allowed me to eat a lot more foods! I still have food intolerances, but not as many or as intense as before. Thiamine deficiency can progress to Wernicke’s encephalopathy or Wernicke-Korsakoff syndrome (WKS) which can be deadly and requires medical treatment. Whether you're here to learn about the benefits, share your experiences, or find support, ThiamineTalk is the place for you. 13 votes, 32 comments. It needs to be metabolised by the liver to become B1 which the body can easily expel any excess of, and I'm not sure if there is a point where Benfotiamine would saturate these enzymes. Tried countless times and it’s just wack. The best nootropic or supplement I've ever tried. Log In / Sign Up; Advertise on Reddit; Any nootropic heads here who have taken nicotine every day for a great length of time J-shaped association between dietary thiamine intake and the risk of cognitive decline in cognitively healthy, This is really interesting. 29M. I ordered some benfotiamine to help with chronic fatigue but it seems to make it worse for some reason. It might be the single most widely-acting anti-nootropic in existence. Nicotine felt nothing like that. I am good at school and have a masters degree in biology so those levels of functioning are intact. The lowest I could find was 100mg. Riboflavin (B2) is a cofactor used in the same enzyme complexes as thiamine. Details: Tyrosine is the catecholamine precursor. Taurine made sense as it was also an amino acid nootropic which I was already familiar with in regards to the other amino acid precursors (ex: L-Tyrosine, L-Tryptophan, L-Arginine). Alcohol is cognitively impairing no matter what other health benefits it may have. I do low carb and have the same response to sulbutiamine. And for methylation, take Methylcobalamine, methylfolate, and SAMe. Rules. Note: [1] TL;DR: It’s good stuff. Every time after, no effect. It’s the first synthetic drug used in medicine, having been used to treat malaria more than a century ago. Vitamin B 1 (Thiamine) is the first B Vitamin to be discovered by researchers. Although I just bought some Thiamine 500mg that is supposedly the active form, thiamine pyrophosphate, it was not stated on the bottle but its description stated something about TPP. As with all neurotransmitters there are different receptors that they have. That’s also a hefty dose of sulbutiamine that would noticeably affect almost anyone, regardless of any thiamine deficiency. Experience I study at least 100 flashcards everyday and I notice a big difference between days in which I haven't exercised for a few days previously, and days on which I have exercised or exercised in the previous day. Without enough magnesium, extra thiamine could cause insomnia (in Thiamine deficiency is easy to get, but difficult to get rid of with regular thiamine. So about 3 years ago I started taking the Onnit b complex. I'm quite sure Sulbutamine was not placebo. Hello guys, I tell my experience with nootropics so far: I started to use nootropic in the december 2020 (6 december 2020) L-Theanine - Some Practical Advice. I mean nootropic in itself has a broad definition. The "thiamine" part is wrapped with the "lipid" part of BFT so the molecular weight of BFT is greater than the molecular weight of thiamine HCl or nitrate. Taking high dose Thiamine (vitamin B1) has improved my mental health and wellbeing and I can feel the energy starting to come back into my body slowly but surely! I've suffered from CFS for 6 years. , don’t carry it. Benfotiamine, a synthetic S-acyl thiamine derivative, has different mechanisms of action and a different pharmacological profile than lipid-soluble thiamine disulfide derivatives. But if OP wants long-lasting effects then it is the one for him! NA Semax was synthesized in 2013 from Semax by acetic anhydride acetylation with the following HPLC purification in order to increase its stability in the biological environment. All of the studies of ashwagandha on anxiety and stress seem to note increasing effects with duration of treatment, with larger effects at 6-8 weeks of continuous supplementation Get app Get the Reddit app Log In Log in to Reddit. I've tried literally hundreds of things like many of you here on this sub. Actually, the fact that modafinil is a prescription drug on the market means it is safe enough to be prescribed. I have even seen some people using phenylpiracetam occasionally, I have tried using piracetam and oxiracetam before working out with success. It was therefore surprising that sulbutiamine appeared to exert specific effects on brain function. But Ive tryed Sulbutimanine (doubled B1-molecule, used as an nootropic) which gave me really really worse symptoms. It's actually said that a major portion if not all of B6 toxicity comes from supplementing the inactive form, Pyridoxine, in excess. In the original MIT study, the researchers found that 300 MCG was the sweet spot, and anything over 600 MCG disrupted hormones and caused daytime sleepiness the next day in everyone in the study. Before posting make sure your comment is polite and helpful. However, as the day went on, I seemed to lose any sense of social tact. Plus it leaves me I've found thiamine hcl works better for me than the mononitrate. TTFD (thiamine tetrahydrofurfuryl disulfide) is a form of thiamine, also known as vitamin B1, which is used to treat thiamine deficiency and related conditions. Looking at the half lives of several B vitamins, thiamine for example has a half life of about 18 days, and your levels would stabilize when rate in equals rate out. Our results r/Thiamine_B1: I've created this sub because https: well known for its nootropic (brain function enhancing) effects; and TTFD (also known as allithiamine, fursultiamine, because I learned Thiamine and magnesium deficiency is another possibility, I'll try supplementing those as well. I know they have an effect on dopamine and other effects and I was wondering how safe they for regular use? I could possibly have had thiamine deficiency for a period of about 3-4. Key Features and Benefits: 74 votes, 98 comments. Theoretical positing about ALA chelating mercury and “ALA will deposit mercury around the body in a hazardous way” are multiple steps removed each other. I think that using nicotine sporadically could be very viable if you don't have a history of addiction. I just happen to need less than others. But since nicotine has that risk of addiction, I would not consider it a first-line nootropic. The anxiety is gone. Welcome to ThiamineTalk! Welcome to ThiamineTalk! This is your go-to community for all things related to thiamine and its various forms, including benfotiamine, TTFD (thiamine tetrahydrofurfuryl disulfide), allithiamine, and more. Thiamine is major player. I can second this. Exercise is the best nootropic I have found. Salicylate intolerance is the main one. As regards your question: thiamine deficiency can be VERY severe. Can you stop doing this like the 4th post here about mood and anxiety - the same question. I wish I knew this sooner it would have made my life easier with cardiophobia. Or Has anyone successfully used high dose thiamine(B1) to reduce MCAS I tried sulbutiamine this fance nootropic form of thiamine which at first gave me sudden and profound relief from my ADD and depression but quickly started making my histamine related issues I started to experiment with thiamine 2 months ago. I didn't feel much from Rhodiola or LM (even 8:1 ethanol extract ), but I have tolerance/resistance to nootropics. It seems to have helped with the following symptoms I had: Digestion problems: much improved My level tested in at 450 and prior to this I took thiamine in various forms up to 150mg per day as a nootropic thing and believe this supplementation may have caused my issues. J-shaped association between dietary thiamine intake and the risk of cognitive decline in cognitively healthy, older Chinese individuals [2024] upvotes · comments r/Nootropics I have been taking Methylene Blue for 2 weeks now and I have to say it’s the most impactful nootropic I’ve taken. For any thiamine supplement (allithiamine, benfotiamine or thiamine HCl), sufficient magnesium is required. does thiamine You need to be taking magnesium also if you have a thiamine deficiency, because thiamine needs magnesium as a co-factor. But the more I researched it, the more I realized pretty much most of the Lycopodium species were high in these natural ACeh reuptake inhibitors. I am a bot, and this action was performed automatically. Searching this sub Just me checking in again, giving an update on Thiamine "treatment" has been going for me. Gastrointestinal disorders: Conditions like Crohn’s disease or celiac Worse around times of seasonal allergies. Sulbutiamine can therefore correct the cognitive effects of thiamine deficiency very quickly. I have to take it In a series of case studies, Italian researchers reported that high-dose thiamine led to marked reductions in fatigue among patients with a wide range of conditions. Start Here Guide to Nootropics Start Here Vendor Warnings Vendor Warnings Vendor Warnings Research Index Research Index I can't believe how much people overlook Theanine. 5 grams was taken be the guy that was doing research on cinnamon and its nootropic effect. 4mg, ginkgolides & Bilobalide 4. I have tried various supplements such as vitamins D3/K2, B Complex, CoQ10, Zinc/Copper, VitC, wheatgrass powder, and iron. It's great to hear that high-dose thiamine initially worked well for you. I came to Reddit to see if anyone was talking about side effects but it It’s not a matter of replication. So in this way unfortunaly I had to Benfotiamine, a synthetic S-acyl thiamine derivative, has different mechanisms of action and a different pharmacological profile than lipid-soluble thiamine disulfide derivatives. I see your source doesn't even state if it's ethanol extract only that it contains beta glucans (which have no nootropic properties). Anyone on long term magnesium supplements will either end up feeling like dog shit OR start consuming thiamine. The brain effect is great IMHO but take it slow. Log In / Sign Up; 3. I had to placebo myself that it’s a nootropic according to what I’ve read online and it still felt like shit. After trying to find another nootropic to add to my supplementation, I was specifically focused on the neurotransmitter GABA and came cross Taurine. J-shaped association between dietary thiamine intake and the risk of cognitive decline in cognitively healthy, older Chinese individuals [2024] upvotes · comments r/Nootropics A test now would tell you if your levels are above the upper limit, a test later would tell you if you are naturally low or your dietary intake is insufficient. . Most of these alkaloids to this day have never been studied extensively for their nootropic capability. Also biotin is a b vitamin that gets depleted with thiamine and is often low in people on low carb diets (cofactor for gluconeogenesis). The only beneficial effects of yohimbine come from blocking alpha-2c, but overall not worth it IMO. I haven’t messed with it because from what I’ve read it’s more of a traditional stim than a nootropic. Get App Log In. I know it's sort of I started off with Thiamine Mononitrate and then got some Benfotiamine, man the Benfo is potent, it speeds up my heart a little bit and makes me really energized, almost anxious. Coins 0 coins Premium Explore. I’m not a scholar on this stuff but besides lifestyle changes and some fringe stuff I think L-Theanine could really be both safe & incredibly effective. Please contact the moderators of this subreddit if you have any questions or Today I bought some L-Thiamine and took 150mg of that along with 300mg caffeine, at about 12pm (midday, along with a bunch of bacon and an egg). Here's what I've heard: It gives you a short term (one day) kick and you build tolerance. I don't understand what's so hard to believe that a anti anxiety nootropic has reduced anxiety. I have been taking Methylene Blue for 2 weeks now and I have to say it’s the most impactful nootropic I’ve taken. I have been taking Ashwagandha for six months. The researchers patented up to 1MG I have seen lists of a lot of the most effective substances whether Nootropic, PED’s and and so on. Having no knowledge of methylation or how it works I bought the supplement thought it looked good and for about the first week after I started taking it I felt amazing, more energy better mood wasn't depressed for the first time in a long time but after that first week or week and a half things started to gradually get really bad I'd be hesitant to take this advice at face value as it may be different for most people. Please contact the moderators of this subreddit if you have any questions or I’d like to start with a disclaimer and say I know L-Theanine has helped a TON of people, so if it works for you, then keep taking it. Aquí nos gustaría mostrarte una descripción, pero el sitio web que estás mirando no lo permite. Dopamine D2 Receptor: Uridine, CDP-Choline, Inositol, I have a thiamine hydrochlorid 100 mg and magnesium citrate 250 mg supplement I took 160 mg of magnesium and 1/4 of the 100 mg thiamine capsule which is 25 mg After around one hour I could feel it. Log fuck all these web networks of nootropic interactions is interesting as fuck but its something i Posted by u/Tubunnn - 12 votes and 7 comments Some kid mega-dosing huge quantities of l-theanine, not even measuring it, and then coming on Reddit making a post about how his brain feels like it’s being squeezed out of his head, and A few months ago I saw some posts on reddit recommending thiamine as a possible aid. Supplementation with a high B-Complex has worked wodners for me, specially with mood stability. Most anti-inflammatory things recommended here (curcumin, for example) tend to be excreted pretty fast. American vendors like NootropicsDepot, Liftmode etc. Or check Nootropic recommendation for long periods of study and Standardised To Contain ginkgo Flavonglycosides 15. The nootropic salbutiamine is one of a few synthetic versions of this form of thiamine. Huberman Recommends Women Avoid Apigenin — It’s an Estrogen Suppressor; Andrew Supplements With 2g of Glycine & 100mg of GABA Every 3–4 Days As with all things, more is not always better. Sulbutiamine is believed to cross the blood-brain barrier more effectively than thiamine, leading to enhanced bioavailability and neurological effects. Its such a warm and cozy feeling. The anxiety thoughts I had are not so intense. Is it MANDATORY to take B1 with magnesium or just a recommendation? I am taking Mg malate now and gives me good energy. And for the past three months I have been taking 1500mg a day and I plan to stay at this amount (if this isn’t a good idea for some reason please let me know but from what I know 1500mg is a fine amount). Seems like no company is interested in making just a modest B-complex that includes all the Bs yet with all doses much closer to the RDA/AI, made with simpler yet still high quality ingredients (not interested in having sulbutiamine mixed in with regular thiamine, or megadoses of B6 and B5 regardless of form, or three different versions of B12 I've also had very good results with thiamine HCL lozenges; those absorb way better than gastro (which is only like 5%) and seem to hit my brain a lot harder. I've never heard of thiamine HCI! It must have been a typo somewhere. If you, for whatever reason, burn through catecholamines, do not absorb protein well, or otherwise end up with a tyrosine deficiency, then you might benefit from 500-1000mg/day of l-tyrosine. Start Here Guide to Nootropics Start Here Vendor Warnings Vendor Warnings Vendor Warnings Research Index Research Index It is known for its potential cognitive-enhancing properties and has gained attention as a nootropic supplement. Are there consequences Add a significant amount of a fat soluble thiamine (B1) form such as benfotiamine, allithiamine or lipothiamine. It's not even close. with great results a few times a week. You probably don't need that much daily. What Do Personal Experiences and Reddit Discussions Reveal About Sulbutiamine? Reddit discussions on sulbutiamine reveal a range of user experiences, with He suggested supplementing with molybdenum and thiamine to activate the SUOX enzyme which breaks down sulfur in the body for elimination. Simply put, awesome. Discussion of nootropics and cognitive enhancers. This OP is like full manic posting to Reddit’s for simple fixes to their depression. 5 months last year February 14th to Late June 2021 (I got my serum B1 thiamine levels tested on July 13th came back high-normal) I had extreme neurological symptoms out of the blue one morning when recovering from flu: derealization, visual snow, tinnitus, off balance feeling, de-ja-vu, horrific Thiamine tends to use up glutathione, and also taxes the methylation a lot. Sulbutiamine has unique effects on the brain that regular thiamine doesn’t have. 40 minutes later, lowered heart rate, feeling so calm and relaxed but not sedated. It has been known for its ability to help improve people’s mood and focus. Also Yes black tea is better as a nootropic than other teas matcha is good too. This made me think that perhaps I developed a Most clinical studies use thiamine doses from 300 up to 1,800 mg per day. Having no knowledge of methylation or how it works I bought the supplement thought it looked good and for about the first week after I started taking it I felt amazing, more energy better mood wasn't depressed for the first time in a long time but after that first week or week and a half things started to gradually get really bad 17 votes, 57 comments. I think the association with green tea makes people think it doesn't really do anything, or is relatively weak. I take glutamine for about 2 months already, regural 10g per day. 10 votes, 17 comments. . Beginner's Guide • Vendor Warnings • Research Index • Rules • Longevity • Stack Advice. My uncle's insights led me to explore the science behind thiamine TTFD and its broader applications. It helped to calm me down and just made me feel nice. Archived post. But what I want to get across is that everyone touts L-Theanine like it’s the greatest thing since sliced bread, like it’s A possible explanation for the pharmacodynamics of sulbutiamine is the increased availability of thiamine triphosphate (ThTP). It’s the active form of thiamine. If something like alcohol allows you to slow your brain the fuck down and have a conversation like it does for me, that can be really beneficial and if it gives you the patience to do schoolwork and not freak out, I say that's some pretty great nootropic effects. Sports. Thiamine TTFD has been shown to influence neurotransmitter production, including dopamine, which plays a crucial role in mood regulation. I've been taking 300mg+/day Thiamine HCl for over a year now. Is that amount Magnesium is well-known for its calming yet energizing effects, the later likely stemming from its pro-dopaminergic properties: In rats, a dietary magnesium deficiency greatly reduces the sensitivity to the effects of cocaine, a dopaminergic stimulant - while magnesium supplementation potentiates the effects of amphetamine. Our results show that, though benfotiamine strongly increases thiamine levels in blood and liver, it has no significant effect in the brain. When you read about what it does it absolutely makes theoretical sense that it could help. [2] This isn't a scientific post. Sulbutiamine enables Thiamine to cross the blood brain barrier so you can utilize it more effectively. Some experiments have shown that higher stability of NA Semax can enhance the nootropic effect. does thiamine (B1) megadosing really work ? Get app Get the Reddit app Log In Log in to Reddit. Lipid-soluble thiamine derivatives were developed mainly in Japan for the treatment of beriberi. Reason is because they have the amino acid theanine and green tea doesnt have much. I have one addendum to make my previous statements more accurate. It's far more pharma like than St Johns Wort or any other herbal antidepressant, nootropic, or adaptogen I've tried So about 3 years ago I started taking the Onnit b complex. Well here's my personal experience with various "choline" supplements: Choline Bitartrate : I feel nothing from this supplement, although it works better than any other choline source for the headaches I experience from taking racetams/noopept or any similar substances. To your last point, I absolutely agree, maintaining a schedule and stimulating your brain are at Cialis(Tadalafil) as a Nootropic - due to blood flow enhancement I purchased some Tadalafil (generic) - 20mg - and cut in half. Reddit is also severely wrong downvoting my accurate comment in lieu of incorrect ones. It could really enter that class of Hello! I’m approximately 6’ and weigh 275lbs My doctor prescribed me 4 350MG pills In the morning and 4 350MG in the evening for a total of 8 or 2800MG a day. In addition, when mice are exposed to Reserpine, a Get app Get the Reddit app Log In Log in to Reddit. I have a theory that for a handful of us, covid depletes our thiamine (vitamin B1) stores or deactivates thiamine-involved pathways, resulting in a cascade of issues. In other words, you can’t diagnose yourself as having a thiamine deficiency just because taking a lot of sulbutiamine made you feel better. Excess Pyridoxine then paradoxically competitively inhibits conversion into P5P, the active form - essentially mimicking a deficient state. I spent less than 200 euro on this set up and my climate is way too cold for cubes and somehow it's nearly ready to fruit. but I use l-thiamine combined with mg with good affect for decreasing anxiety attacks. In rodents, voluntary locomotor activity as an active physical behavior may be mediated by dopaminergic neurons (DNs). When magnesium does seemingly anomalous things (like brain fog or insomnia), I get low in thiamine because I like foods that have anti-thiamine factors (Wikipedia it; tea, coffee, raw fish, then sugar and alcohol just deplete it; there’s a reason the benfotiamine for was I have a theory that for a handful of us, covid depletes our thiamine (vitamin B1) stores or deactivates thiamine-involved pathways, resulting in a cascade of issues. Here thiamine derivatives come to the rescue, which bypass the enzyme systems, and turn I have had numerous positive and negative experiences with different forms of thiamine for my mental fog and energy. It is essential for glucose metabolism, and it plays a 10-15MG melatonin is definitely a hormone overdose, but so is anything over 300 MCG (as in micrograms, not even milligrams). You should check out TPP (cocarboxylase). We can be pretty sure that prescribed Moda is generally well tolerated and def safe in the short term. This NAC posting caught my attention because I am currently taking NAC for a completely different effect. Honestly creatine needs to start being taken seriously as a nootropic and not just as a strenght builder. I do a google search and here is what I found about excess dopamine neurotransmitter: Having too much dopamine — or too much dopamine concentrated in some parts of the brain and not enough in other parts — is linked to being more competitive, aggressive and having poor impulse control. r/Nootropics: Discussion of nootropics and cognitive enhancers. Whenever I find something like this, I treat it as a safety net, I want to take it 2-3 times a week to make sure I'm not getting deficient but I sometimes find if you take too much of some stuff it can mess with your digestion/system, especially if you're taking a bunch of different things at once. However, I can't seem to nail one down that works This is to help reduce spamming in the subreddit; if you wish to discuss your brand name supplement, simply list the ingredients and dosages, not the brand name. I take around 300mg per day for 3 days now. Log In / Sign Up; 1 gram of Thiamine will give you boost without insomnia. I can’t vouch for their legitimacy since I've never bought from them. By boosting dopamine levels, thiamine TTFD can help alleviate depression symptoms and enhance mental health. In its end stage it's called Beriberi and you can google what this means. 1 Try to post to the correct subreddit Get app Get the Reddit app Log In Log in to Reddit. Adrafinil and the other designer versions of 'afinil without a doubt have not been I know thiamine has various analogues/derivatives for better absorption etc. I haven’t looked at this Reddit account in a while and noticed quite a few comments on an old post I made about mucuna pruriens, so I thought I’d write a new report if people are still looking for more information. It causes demyelination, loss of DHA-bound phosphatidylserine, rebound glutamate excitotoxicity, dehydration, loss of thiamine, potassium, magnesium, and other nutrients, and who knows what else. This is the best Nootropic for me by far. Would love if sulbutiamine didn’t have these effects. Like any other drugs bringing about euphoria, sulbutiamine affects your dopamine levels. I didn't notice anything negative, theobromine poisoning is a thing but you'd have to take an insane amount of it for any harm to come out of it. The treatment is thiamine supplementation. Log In / Sign Up; Impairment of acetylcholine synthesis in thiamine deficient rats developed by 26 votes, 65 comments. People also take sulbutiamine (a thiamine type substance) for I have never supplemented Thiamine. Here you’ll learn what each nootropic is, what it does, and suggested dosages. Log In / Sign Up; but the common dosing recommendations are fairly different and sulbutiamine seems to be more commonly used as a nootropic whereas allithiamine is more common to treating overt thiamine deficiency. User account menu. Why YSK: It takes extra thiamine and folic acid to process alcohol, leading to deficiency if the individual does not supplement. You should take it in a 1:1 ratio of caffeine. Curious to hear if anyone Welcome to ThiamineTalk! Welcome to ThiamineTalk! This is your go-to community for all things related to thiamine and its various forms, including benfotiamine, TTFD (thiamine Get app Get the Reddit app Log In Log in to Reddit. That article posits phenomena that has no support in the literature. Pretty “high functioning” but not invisible autism, I’m still quite bad with eye contact and some parts of executive function. General probiotics are used with antibiotics to prevent diarrhea. For the first two months I took 300mg a day. It’s been some years since I experimented with nootropics, but I went 18 months using oxiracetam, pramaracitam, This lesser-known B vitamin is important for keeping your body, brain and heart healthy. 387K subscribers in the Nootropics community. Here is a rating of some of the top As for the 100mgs of thiamine, I assume you're taking B100 which in my experience usually contains Thiamine HCl. I just want to give those who are new here some advice which will make their life easier, by helping them use Theanine more effectively. Factors that can affect vitamin B1 bioavailability include: Alcohol consumption: Chronic alcohol use can impair thiamine absorption and increase its excretion. Were you on a training protocol BEFORE taking the Creatine, and only after adding the supplement noticed these effects? Because the mood and cognitive benefits of regular exercise are well studied and (arguably) outweigh the nootropic effect of just about any drug. Searching this sub and r/covidlonghaulers for "thiamine" shows others have similar ideas, and I've seen some recent posts about this vitamin, so I wanted to tie together this post. IIRC the RDA for B1 is 2mg (Benfotiamine is mostly thiamine by weight), and being fat-soluble it will accumulate over time. Huberman Recommends Women Avoid Apigenin — It’s an Estrogen Suppressor; Andrew Supplements With 2g of Glycine & 100mg of GABA Every 3–4 Days 24 votes, 26 comments. Thiamine can compete with other B vitamins and lead to depletion. This is because it is a thiamine analog that can pass the blood brain barrier, but has subtly different effects. Or check it out in the app stores I'm unfortunately tried nicotine as a nootropic. Learn more about the benefits of thiamine — and how much you need. I am wondering for those of you who took thiamine to address SIBO/IBS— what was your experience? What was your dose and how Hi everyone. “Thio-vitamine” refers to its sulfur-containing content. Or check it out in the app stores Thiamine and benfotiamine prevent stress-induced suppression of hippocampal neurogenesis in mice exposed to predation without affecting brain thiamine diphosphate levels. No side effects are reported even at Advanced neurohackers add Sulbutiamine to their stack instead of standard Vitamin B 1 (thiamine) because it’s better absorbed and used by your brain than B 1. It's an amazing nootropic, I just wish it had a shorter half life; when I take it I make the tradeoff of being able to sleep well that night for being totally motivated and focused all day. Also, alcohol depletes thiamine majorly a long with a few other drugs I read up on. ( folic acid and nicotinic acid) . The recommended dosage of TTFD may vary depending on the specific condition being treated and individual factors such as age, weight, and overall health. Help me decide which to get. It was Maybe it would be cheaper to buy thiamine separately and see if you react to it or if it's something in the b-complex. It probably doesn't help that a lot of the classic nootropics are also very subtle and Welcome to r/Nootropics, a reddit devoted to discussing nootropics and cognitive enhancers. Reviews are mixed, but I felt sedated by Uridine Monophosphate. The bottom-line is thiamine dosing is completely up to you. OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin (2014) Last revised by Welcome to r/Nootropics, a reddit devoted to discussing nootropics and cognitive enhancers. Thankfully I found this supplement via nootropic and supplements, honestly much safer than going into SSRI options. Just in the same way as many nootropics enthusiasts use caffeine, which also produces dependence if used regularly. It's easy to grow them with some patience and research. But then before bed I had a headache and insomnia where I felt kind of manic and I hadn't had issues with sleep in roughly two weeks. It feels like a hug. Sulbutiamine is also known as: Arcalion Enerion Bisibuthiamine Youvitan Sleep apnea is a widely underdiagnosed sleep condition that can dramatically affect cognition (and lifespan). And also quite underrated: creatine Yes, the hair loss was a show stopper for me, making not want to do roids anymore. Very low b9 and b3. Interestingly many of our western medications come from Ayurvedic medicine, and in Ayurveda they believe garlic is a medicine not a food. Does coffee affects thiamine absorption? How? Is this effects significant? Could coffee consumption cause thiamine deficiency? I've been using Thiamine analogues separately like Sulbutiamine, Allithiamine, TTFD etc. I don't think it's that big of a deal to do occasionally. Do coffee impair thiamine absorption? I read a lot of articles saying coffee blocks thiamine absorption, but didn’t find any study backing this up. true. Hey guys, I'm new to the nootropics game and have read that certain B vitamins like B6 and B12 should be used to supplement Welcome to the Nootropics Australia subreddit! Our community is devoted to discussing the latest advancements in nootropics and cognitive enhancers, such as Piracetam, Aniracetam, Choline, Modafinil, Caffeine, and more. So you could try to supplement glutathione co factors; NAC, glycine, vitamin E, Sodium Lipoate, vitamin C, etc. As others have pointed out the correct dose seems to vary for different people, generally somewhere in the range of 1:1 ratio to 3:1 ratio. Thiamine This is the most comprehensive list of Nootropics in use today. It seems to have helped with the following symptoms I 100mg capsule with 100mg caffeine (in coffee). Sulbutiamine is two modified thiamine molecules bonded together into a fat soluble molecule that can cross the blood brain barrier more easily than the natural water soluble forms of thiamine. Then it was actually on reddit where I read a comment (with more explanation) about the mechanism of zink protecting the hair follicles during AAS, Get app Get the Reddit app Log In Log in to Reddit. Started with a month of multi Bs + 25-50 mg of thiamine HCl (a month after) + magnesium. I do not have any experience with low dose Li (nor high dose), but I think the literature/experience with the suggested use case even in the medical community is pretty low quality. But not only some of them seem to have different effects, but they bypass transporters which you don’t always want and it seems they don’t fit or work well for some people like hydrochloride does. I was returning from my work home, by car, quite tired and not in very good mood. Not every nootropic had positive effects on me (for example every *racetam had a little different weird results for me), but I can feel the difference between almost every nootropic I've tried. I get there can still be good conversation but these suggestions are the same. Some people compare the effect it has on you to amphetamines. I have read a couple of times (mostly on reddit) that Thiamine works synergistically with magnesium and that thiamine may even help reduce some of the side effects experienced with magnesium. Yes it gives you energy but it's basically an anti-nootropic, tearing down your pfc's working memory network which is heavily dependent on alpha-2a receptors. rsmp wshb ncz qtza fvnja xxd rrki nlti rny kqr